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A/Prof Lois Holloway

Research Physicist

Our research uses basic science and clinical research to improve patient outcome. The key focus of our research is on radiation oncology treatment and related imaging techniques. Our major research project is the development of a Magnetic Resonance Imaging – Linear Accelerator (MRI-linac). This is one of only 2 other similar developments worldwide and will enable real time imaging of patient anatomy during radiotherapy treatment and the potential of improved cancer targeting and a reduction in treatment side effects. Improved cancer targeting will be possible through increased soft tissue contrast available with MRI and the potential of incorporating physiological cancer targeting through advanced MRI pulse sequences.
Other research projects include assessing the benefits of MRI and other imaging modalities for radiotherapy treatment planning and delivery, the use of advanced radiation dosimeters for treatment verification, the impact of uncertainties in radiotherapy delivery and the potential of data mining for using standard patient treatment data to better inform treatments for future patients. This work is undertaken within the cancer therapy centres at Liverpool and Macarthur and other collaborating centres. Component projects are focused on a range of specific clinical sites such as lung, breast, gynaecology, head and neck and prostate.

Publications

C1 - Journal Article

E1 - Conference Abstract

  • 2016, Inter-Observer Delineation Comparison of Visible Glandular Breast Tissue On Magnetic Resonance Imaging and Computed Tomography (prone and Supine), American Association of Physicists in Medicine (AAPM 2016) 58th Annual Meeting and Exhibition, American Association of Physicists in Medicine (AAPM), 1631 Prince Street Alexandria, VA 22314
  • 2016, Step and Shoot IMRT, VMAT and Autoplan VMAT Nasopharnyx Plan Robustness to Linear Accelerator Delivery Errors, American Association of Physicists in Medicine (AAPM 2016) 58th Annual Meeting and Exhibition, American Association of Physicists in Medicine (AAPM), 1631 Prince Street Alexandria, VA 22314
  • 2016, A Multi-Institutional Study Quantifying the Impact of Simulated Linear Accelerator VMAT Errors for Nasopharynx, American Association of Physicists in Medicine (AAPM 2016) 58th Annual Meeting and Exhibition, American Association of Physicists in Medicine (AAPM), 1631 Prince Street Alexandria, VA 22314
  • 2015, "Quality assurance of the radiotherapy workflow integrating a dedicated wide-bore 3T MRI simulator", World Congress on Medical Physics and Biomedical Engineering, Springer, Cham, Switzerland, vol. 51, pp. 539-542
  • Thwaites D, Holloway L, Bailey M, Barakat S, Carolan M, Delaney G, Field M, Dekker A, Lustberg T, Miller A, van Soest J, Vinod S, Walsh S 2015, A Developing Australian Network for Datamining and Modelling Routine Radiotherapy Clinical Data and Radiomics Information for Rapid Learning and Clinical Decision Support, 57th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, vol. 42, no. 6, pp. 3335-3336
  • Arumugam S, Xing A, Vial P, Thwaites D, Holloway L 2015, A Software System to Monitor VMAT Plan Complexity in a Large Radiotherapy Centre, 57th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, vol. 42, no. 6, p. 3348
  • Whelan B, Gierman S, Schmerge J, Holloway L, Keall P, Fahrig R 2015, Novel MRI Compatible Electron Accelerator for MRI-Linac Radiotherapy, 57th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, vol. 42, no. 6, p. 3690
  • Lehmann J, Bhatia S, Walsh S, Field M, Barakat M, Greer P, Ludbrook J, Dekker A, Holloway L, Vinod S, Thwaites D 2015, Sifting data from the clinical coalface: datamining in radiation oncology to aid clinical decisions, WILEY-BLACKWELL, vol. 11, p. 10
  • Barber J, Sykes J, Holloway L, Thwaites D 2015, Automatic Image Registration Performance of Three IGRT Systems for Prostate Radiotherapy, 57th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, vol. 42, no. 6, p. 3270
  • Arumugam S, Xing A, Young T, Blake S, Thwaites D, Holloway L 2015, Measurement Based Dose-Volume Metrics for the Quality Assurance of VMAT Plans-Are We There Yet?, 57th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, vol. 42, no. 6, p. 3531
  • Blake S, Hansen C, Deshpande S, Phan P, Franji I, Holloway L, Thwaites D 2015, Evaluating Plan Quality and Dose Delivery Accuracy of Tomotherapy SBRT Treatments for Lung Cancer, 57th Annual Meeting and Exhibition of the American-Association-of-Physicists-in-Medicine (AAPM), AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, vol. 42, no. 6, pp. 3418-3419
  • 2013, "A survey of cervix segmentation methods in magnetic resonance images", The Fifth International Workshop on Abdominal Imaging: Computational and
    Clinical Applications
    , Springer-Verlag, Berlin, vol. LNCS 8198, pp. 290-298

Awards

  • 2014 Best submitted abstract, Cancer Institute Innovations conference; Mining routine radiation oncology clinical datasets within a distributed rapid learning framework: the potential for supporting optimised clinical decisions.
  • 2014 Best Presentation award, NSW Radiation Therapists Research Meeting; Radiotherapy Planning as a Tool to Quantify the Impact of using MR as Imaging Choice for Breast Cancer Radiotherapy.

Grants

  • 2017 Bioradiance Malinen, E; Holloway, L*; Oslo University Hospital.
  • 2017 Radiotherapy Data mining Holloway, L*; South Western Sydney Local Health District (SWSLHD).
  • 2017 Top up Student Scholarship for Dale Roach Holloway, L*; South Western Sydney Local Health District (SWSLHD).
  • 2016 Reducing the greatest uncertainty in radiotherapy. Holloway, L*; Haworth, A; Dowling, J; Ebert, MA; Vinod, SK*; Kron, T; Jameson, M; Leong, T; Greer, P; Creutzberg, C; NATIONAL HEALTH & MEDICAL RESEARCH COUNCIL.
  • 2015 Radiotherapy treatment for prostate cancer - a change in practice based on direct evidence for targeting and toxicity effects using real outcomes data Ebert, MA; Dowling, J; Denham, J; Gulliford, S; Holloway, L*; Haworth, A; University of Western Australia.